Men with ED might find it helpful to talk to their doctor about the condition. They might also consider counseling, which could help improve communication and work through relationship issues.
The first step is to do a physical exam and answer questions (medical history). Blood tests might be done to check for health conditions that can cause or worsen erectile dysfunction, such as diabetes, heart disease, and low testosterone levels.
PDE5 Inhibitors
The first line of ED medications is the oral PDE5 inhibitor class, which includes sildenafil (Viagra), tadalafil (Cialis), Vardenafil (Levitra), and Avanafil (Stendra). These drugs all inhibit the activity of PDE5, which degrades cGMP. Online vidalista allows the physiological nitric oxide (NO) to exert its smooth muscle-relaxing effect on the corpus cavernosum, leading to an erection.
PDE5 inhibitors were originally developed to treat chest pain and high blood pressure by improving blood flow, but they also seemed to help a lot of older men with erectile problems. Since then, doctors have found that they can be useful for younger men too.
It’s important to note that these medications do not work for everyone and should be use only when they are need, especially if the underlying cause is relate to cardiovascular disease or prostate issues. Also, these drugs are not recommend for people with hepatitis or severe liver impairment, as they may not be safe. In these cases, other treatment options, such as intraurethral tumescence or a pharmacodynamically equivalent alprostadil injection, should be consider.
PDE6 Inhibitors
During sexual arousal, the body produces a natural chemical called nitric oxide (NO). Extra super vidalista also activates an enzyme called guanylate cyclase, which converts guanosine triphosphate to cGMP. cGMP relaxes smooth muscle tissue in the corpus cavernosum, which allows blood vessels to dilate and improves blood flow.
But an enzyme called PDE5 breaks down cGMP, which neutralizes its effectiveness and reduces blood flow to the penis. Drugs called PDE5 inhibitors bind to and block the breakdown of cGMP, which enhances the action of NO and improves blood flow.
There are four FDA-approve drugs that are PDE5 inhibitors: sildenafil (Viagra), tadalafil (Cialis), Vardenafil (Levitra) and Avanafil (Stendra). These medications are the principal oral agents use to treat ED. They may also be use to treat pulmonary hypertension, an inherit condition that causes blood vessels in the lungs to enlarge and tight, and a serious condition called chronic obstructive pulmonary disease. Also known as COPD, this is a long-term lung disease.
PDE9 Inhibitors
The primary erectile-mediating neurotransmitter is nitric oxide (NO), synthesized in the corpus cavernosum by neuronal nitric oxide synthase to initiate erection and by endothelial nitric oxide synthase for maintenance during sexual stimulation. NO passively crosses the cell membrane to activate soluble guanylyl cyclase, which increases production of cyclic guanosine monophosphate (cGMP). cGMP potently stimulates protein kinase G, which leads to smooth muscle relaxation and vasodilation.
Nitric oxide inhibition with PDE5 inhibitors such as tadalafil improves erectile function in men with ED. And reduces cardiovascular risk factors, such as blood pressure and heart rate. However, in patients with significant cardiac risk, a prolonge QTc interval may be seen.
Selective PDE9 inhibitors are under development based on natural and nature-inspired scaffolds. In addition to focusing on specific structural features of this isoform. These compounds are also design with an eye towards avoiding cross-reactivity with PDE1 isoforms that might cause detrimental off-target effects. Xanthines and lignans are some of the most widely investigate natural and nature-inspire compounds.
Sildenafil
Sildenafil is the only PDE5 inhibitor to be approve by the FDA to treat both ED and PAH. It is available as the brand-name drugs Viagra and Revatio, as well as generic tablets and liquid. And It starts working within 30-60 minutes and stays in the body for up to four hours. It is take once per day, ideally about an hour before sexual activity.
It works by blocking the enzyme phosphodiesterase type 5, which breaks down a molecule called cyclic guanosine monophosphate (cGMP). This allows the muscles around the penis and lungs to relax and widen, increasing blood flow. It also helps with PAH by improving blood flow to the lungs. Making it easier for patients to exercise and for better you can visit best pharmacy Generic cures at USA.
Sildenafil may interact with some medications, including nitrates and alpha blockers like adrenergics. It should be avoid with certain medicines for pulmonary arterial hypertension, such as riociguat (Adempas). Tell your doctor about all the prescription and nonprescription medications, vitamins, and herbal supplements you take.
